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Toll-like receptor 9-independent suppression of skin inflammation by oligonucleotides.

Pivarcsi A

Clinical Allergy Research Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden. andor.pivarcsi@ki.se

It has been well established that cytidine-phosphate-guanosine (CpG) oligodeoxynucleotides (ODNs) activate innate and adaptive immune responses in keratinocytes by stimulating Toll-like receptor 9 (TLR9)-dependent signaling pathways. However, as Dorn et al. report, keratinocytes possess another, yet uncharacterized, TLR9-independent mechanism for the recognition of ODNs. Surprisingly, the activation of the pathway leads to suppressed chemokine production in vitro and decreased skin inflammation in vivo.

Published 16 March 2007 in J Invest Dermatol, 127(4): 746-8.
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