Skin Rashes Research Today is a free monthly online journal that collates and summarizes the latest research about Skin Rashes, including details on dermatitis, itches, creams, medication, treatment.

Fleshing out filaggrin phenotypes.

Irvine AD

Department of Pediatric Dermatology, Our Lady's Children's Hospital, Dublin, Ireland. irvinea@tcd.ie

The association of filaggrin null alleles with eczema has been replicated in several European populations. Three large, well-conducted studies confirm this association and offer insights into the phenotypic nature of eczema associated with these alleles. Early data suggest that FLG-associated eczema may be more persistent, more likely to have palmar hyperlinearity, and more likely to be associated with asthma. These initial hints will require further confirmation in cohort studies.

Published 14 February 2007 in J Invest Dermatol, 127(3): 504-7.
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