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Acute generalized exanthematous pustulosis caused by morphine, confirmed by positive patch test and lymphocyte transformation test.

Kardaun SH, de Monchy JG

Department of Dermatology, University Medical Center Groningen, University of Groningen, The Netherlands. s.h.kardaun@derm.umcg.nl

Morphine, an opium alkaloid, frequently causes side effects such as hyperhidrosis and facial flushing, but serious cutaneous adverse drug reactions are seldom observed. Best known are urticaria, erythema, and pruritus; sometimes pseudoallergic anaphylactoid reactions, and blisters are reported.

Published 17 July 2006 in J Am Acad Dermatol, 55(2): S21-3.
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