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Hyper-IgE syndrome with widespread premalign oral papillomas treated with interferon alpha2b.

Ozarmağan G, Didem Yazganoğlu K, Agaçfidan A

Department of Dermatology, Istanbul University, Istanbul Medical Facility, Turkey. gozarmagan@mailcity.com

We report a case of a 7-year-old girl with hyperimmunoglobulin-E syndrome presenting with widespread oral papillomas which were tested for human papilloma virus DNA and had shown to be at high/intermediate risk group for malignancy. She had elevated levels of IgE, recurrent sinopulmonary infections, atopic-like dermatitis, peripheral eosinophilia and defective neutrophil chemotaxis. Interferon alfa 2b therapy and chemoprophylaxis with sulfamethoxazole-trimethoprim was given. Although the papillomas partially improved with the treatment, sinopulmonary infections continue to occur.

Published 14 September 2005 in Acta Derm Venereol, 85(5): 433-5.
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