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Five patients with localized facial eruptions associated with Gianotti-Crosti syndrome caused by primary Epstein-Barr virus infection.

Yoshida M, Tsuda N, Morihata T, Sugino H, Iizuka T

Yoshida Pediatric Clinic, Osaka, Japan.

Five infants exhibited an exclusively facial rash associated with Gianotti-Crosti syndrome(GCS). On all patient cheeks, multiple erythematous papules were seen symmetrically. All patients tested positive for the immunoglobulin (Ig)M antibody against the Epstein-Barr viral capsid antigen, suggesting that a primary Epstein-Barr virus (EBV) infection caused localized facial rash, an alternative clinical picture of GCS.

Published 6 December 2004 in J Pediatr, 145(6): 843-4.
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