Skin Rashes Research Today is a free monthly online journal that collates and summarizes the latest research about Skin Rashes, including details on dermatitis, itches, creams, medication, treatment.

Severe sialadenitis: a new complication of drug reaction with eosinophilia and systemic symptoms.

Abecassis S, Roujeau JC, Bocquet H, Copie-Bergman C, Radier C, Revuz J, Cosnes A

Departments of Dermatology, Hôpital Henri Mondor, Créteil, France.

BACKGROUND: Drug cutaneous reaction and isolated cases of parotitis induced by terbinafine have been reported. OBSERVATION: We report a case of drug reaction with eosinophilia and systemic symptoms induced by terbinafine associated with a severe sialadenitis and a complete sicca syndrome. Evolution was protracted with a slow recovery of the rash but sicca syndrome persisted with only a very mild improvement at 6 months. CONCLUSION: Liver, kidneys, lungs, and heart are the organs the most frequently involved in drug reaction with eosinophilia and systemic symptoms. Salivary and lacrimal glands can also be severely involved in the course of drug reaction with eosinophilia and systemic symptoms.

Published 3 November 2004 in J Am Acad Dermatol, 51(5): 827-30.
Full-text of this article is available online (may require subscription).

© 2004-2008 Skin Rashes Research Today. All Rights Reserved.